Follica, Intercytex ou Neosil, qual vai chegar primeiro?

onde ue compro isso?

vou espetar umas agulhas com isso em alguns velus meus como teste

:lol:

Cara, deixa de inventar moda, pra que se fazer de cobaia com idéias inventadas a esmo???

Mesmo porque isso só é vendido a médicos dos EUA, e é caro pra kct.

zooi escreveu:onde ue compro isso?

vou espetar umas agulhas com isso em alguns velus meus como teste

Dudu228 escreveu:está tendo um animação enorme da carecada gringa, com motivo, porque se tudo que o cara da entrevista falou for verdade, a cura está descoberta.

Eu ouvi denovo e entendi: o cabelo foi puxado normalmente e não se extrai o foliculo, esse cabelo puxado foi implantando em otra área e com a tecnologia da acell, o corpo criou um foliculo totalmente novo ao redor do cabelo implantado, o que sim, seria uma cura por clonagem de fios feita pelo propio corpo, tendo uma area doadora ilimitada pois como todos sabemos um cabelo puxado volta a nascer novamente.

o medico falou que isso já está disponivel hoje, mas estão estudando se esse fio implantado irá se comportar como uma cabelo da área doadora, ou um cabelo da area implantada (uma vez que o foliculo criado foi criado numa area que é atacada pelo DHT).

tomara.

http://www.worldhairloss.org/index.php/ ... thread/214

Parece que o Dr Cooley era um dos médicos responsáveis por quela clonagem de 1 folículo, que foi notício no começo do ano.


Transcrição daquela entrevista de rádio com o Dr Cooley:

Jerry: I started working with this wound healing product about a year and a half ago, and initially got some promising results, its taken me definitely some time to understand it and understand what worked well and what didn’t as well as just to see long term results and one of the things ive been doing in the last few months is just making a real concerted effort to bring people back in which is not really that easy, but just to really look very closely at my results and I’ve just gotten that much more excited about it.

Spencer: well I guess the big buzz is everyone is you know asking if this something that’s actually regenerating hair you know Dr Gary Hitzig put out the initial press release a few months ago, it looked like this was almost the holy grail, this was going to be hair cloning, and from what I gather its not exactly the case.

Jerry: Yea, you know it really does require further explanation; the best way that I can describe it is this represents a very important piece of the puzzle, it is a breakthrough. Its an active area of regenerative medicine, hair restoration is just a very very tiny application, there using this product for all sort of applications which I can describe for you if your interested.

Spencer: absolutely

Jerry: Yea, but I have not documented new hair in other words a complete out of nothing hair follicle appearing were there wasn’t one

Spencer: right

Jerry: but, it does appear to be able to restore transacted or injured hair follicles

Spencer: really

Jerry: and something were very excited about which is to copy or what we call autoclone plucked hairs.

Spencer: Yea explain that, you know a lot of people have been writing us about that there been some stuff circulating online about that, I know that you’ve been doing hair plucking ,and know that ive read some stuff about Dr Hitzig experimenting with it as well, explain it to us what exactly is it.

Jerry: Sure the best way I can describe it is if you just look at the basic structure of the hair follicle there are two basic layers of cells around the hair shaft, the outer layer is what we call the mesenchymal layer and that’s what contains the dermal papilla; that’s what intercytex and Aderans are trying to isolate and culture and use for cloning applications and cell implants. The inner layer is what we call the epithelial layer and that where you have the bulge with the stem cells, the outer and inner root sheath and when you pluck a hair properly you can get this inner portion or the epithelia portion, now about ten years ago Dr. Hitzig began experimenting some of his patients who had multiple old transplants and had no donor hair to give he just got interested in the concept of plucking beard whiskers and using them as grafts and he had a pretty low rate of success, but once in a while it worked and he kept working over the years on ways to get it to work better, then a couple of years ago began using this product called acell and I had kept in touch with him over the years because I was very interested in this idea and once I heard about the acell I knew I had to get involved and the basic idea is this that when you pluck a hair its going to grow back from the site you plucked it because all of the elements inside are necessary to regenerate the hair follicle and anyone whos plucked there hairs knows it grows back, but the reason that it will grow where we planted it is that when we coat it with this acell product and then transplant it stimulates the bodies innate regenerative potential to rebuild the follicle that outer portion around the plucked graft.

Spencer: that’s amazing,

Jerry: it is amazing

Spencer: that really is, I mean that’s basically if this is truly consistently possible you would basically have unlimited donor

Jerry: Right, and it was just astounding and I knew a lot of people would be sceptical, and Dr. Hitzig although very excited about it you know didn’t really take the time to take macro photographs or biopsies and so thats some of the thins I wanted to do to really convince the sceptics.

Spencer: sure

Jerry: and so I was using a high powered attachment to my digital camera to document the photographic evidence that these hairs would grow and then I did a series of biopsies and worked with a very prominent dermatopathologist to analyze these biopsies to say what do these things look like under the microscope. And I can show some of those images and basically they look like normal hair follicles, Im trying to be careful not to overplay it, and I don’t want to overstate these results

Spencer: yea but its not like you just heard it through the grapevine, you actually were able to produce these results

Jerry: Correct

Spencer: okay

Jerry: yea, and prove for what I consider to be beyond a shadow of a doubt that this phenomenon occurs you simply cant look at these biopsy results and dispute what you see.

Spencer: Now are these plucked hairs growing into terminal hairs, full terminal hairs.

Jerry: yes, yea, indistinguishable

Spencer: wow,

Spencer: I will tell you that ive been in this industry for thirteen years and this is probably the most exciting news that ive ever heard, and im not just trying to over hype this. If this is what it is, if this is what you say it is this is monumental news.

Jerry: well I certainly think so , and I think so for two reasons, one I think the autocloning as it stands right now with the plucked grafts has clinical applications today. I mean im doing this in the clinic right now. But, I think more importantly it shows us something that you know until recently we hadn’t even thought of we were pursuing this idea of culturing dermal papilla and

Spencer: absolutely

Jerry: and applying and injecting them when the body has this miraculous regenerative potential and we can take this research this technology to the next level and learn how to trigger the body to regenerate hair follicles and in fact Dr. Anthony Atala who one of the worlds leading regenerative medicine experts was recently quoted in an article saying he thinks this is the direction that regenerative medicine is going, you know rather than constructing these complex organs in the laboratory and then putting them in or culturing all these cells that really the most promising direction is using these triggers and in this case acell using these triggers to get the body to regenerate.

Spencer: well first of all its an amazing sounding process and a) its you know its gotta be less expensive in the long run b) your not worrying about like you said regenerating these entire tiny little organs in a Petri dish

Jerry: right and you know the cell culturing process is incredibly complicated, and you know having these culturing facilities and so on, and whether or not it may turn out to be successful but, if there’s a simpler way it certainly would be much less expensive.

Spencer: I don’t mean to cut you off but this aderans must be looking at this and be thinking holy cow, you know we spent all this time this money and obviously going in a specific direction to make this happen, but I mean this could completely eclipse what they’ve been working on.

Jerry: well that’s one possible scenario, and another possible scenario is its going to take a combination of this technology and cultured cells so I think right now everything’s up for grabs, this is a breakthrough, but exactly what’s going to happen from here you know remains to be seen, it may be that will be using a combination of cells and extracellular matrix, but I think this is one critical piece of the puzzle.

Spencer: well id say you’ve always been a very diplomatic guy Dr. Cooley, I mean whats your gut tell you from what you’ve seen in your own practice.

Jerry: my gut tells me that his is where the action is at, this is what other researchers are focusing on for degenerative conditions and this is where we as you know people very interested in bringing this idea of hair restoration, this is where we should be heading, but im not, im not, I want to make it clear, im not, I don’t think this as of right now means the end of cell technology.

Spencer: right im actually surprised that im hearing this because I knew that this was happening, but I had no clue that you’ve had such great success with it, and I think that whats going to happen especially once this interview gets out a) your going to be inundated with phone calls, and I don’t want consumers and hair loss sufferers to think that okay now this out , there the holy grail is their Im going to be able to get unlimited donor supply, its going to take some time.

Jerry: oh absolutely, and I certainly that is not the message, this is in my opinion a breakthrough it is available now and it takes hair restoration to a whole new level in my opinion and it gives us options as will discuss as we get into my presentation, not just for this autocloning but just making current hair transplants that much better.

Spencer: I mean do you think that guys who are considering minimal procedures would be great candidates for something like this

Jerry: well this would probably be a good time to discuss unanswered questions, so we can create these new hair follicles we can duplicate hair follicles, are these hair follicles permanent? Are they subject to balding? Will they cycle normally? These are some important questions that I want to now that I know we can do it, these are the questions now that I want to look at is because they’re regenerated in the recipient area are they a hybrid? Will they show sensitivity to DHT? When they go through there growing phase of three years will they fall out and not come back? So one of the things im going to do is start plucking some of my plucked grafts you know that are growing and see if they regrow and just to make sure that they’re as durable and healthy as we want them to be.

Spencer: so as far as a timeline, when do you think, how long do you think its going to take for you to be comfortable in saying you know what this works, this works to the extent that you believe that we can give somebody a fuller head of hair without using some of the conventional methods.

Jerry: well ive very conservatively and very carefully starting introducing it into my practice that way, so ive started doing , you know ive stared off doing 100 test grafts, 200 test grafts, then 400 test grafts. My largest one to date is about 1500, and that’s an example of a women who had this really beautiful hair, she had had a prior STRIP with a bad experience at another clinic, came to see me we did a small STRIP with good results but even though she has this luxurious beautiful hair, her scalp is tight as a drum, so her option is basically FUE, and she heard about the plucking research and was interested so basically we did about 1500 grafts to her frontal scalp with plucking and a anticipating a good results. But that patient went into this process fully informed that yes its less invasive these are the advantages but we cant guarantee the permanence, you know I predict that they will be permanent but that will remain to be known, so anyone doing a new procedure

Spencer: even if it lasted three years, even if it lasted you know one growth cycle I mean to go back in to get it done obviously, there’s a cost issue involved, but if its relatively less invasive and you know theres not a tremendous amount of downtime you know you can kind of replace some of the hairs that might be lost over time, and I think thats always a possibility, yea its gonna be kind of like an ongoing process which isn’t the best case scenario but it would still beat being bald especially for a women.

Jerry: well I think time will tell and answer these questions, im certainly optimistic that these will be you know long lasting results.

Spencer: okay, well good.

Será que a Dª Cura desceu do lombo do jegue e montou num cavalo?
Será essa a tao esperada cura que muitos esperam antes de fazer um transplante?

Acho prematuro dizer isso.

Ivan Drago escreveu:Será que a Dª Cura desceu do lombo do jegue e montou num cavalo?
Será essa a tao esperada cura que muitos esperam antes de fazer um transplante?

Noticia como essa me faz continuar nessa incansável luta !
Do contrário ja teria raspado zero e investiria meu dinheiro e tempo em outras coisas !

no dia da cirurgia vo conversar com o Dr. ver o que ele acha dessa novidade.

sem querer arranquei um fio e ele saiu com aquele bulbo, será que já começo a guardar? =P

Acho irônico...

Várias empresas tentando criar folículos a partir de técnicas elaboradas, proteínas embrionárias formada em baixa gravidade, cultivo de queratinócitos, cultivo de fibroblastos, tudo que requer avançadas técnicas e método, para saber que mensageiros químicos estimulam isso e aquilo, formas de extrair amostra celulares do folículo para esses cultivos. Milhões de dólares gastos e nenhum grande sucesso, a não ser novos fiapos esparsos aqui em alí...

Mas o que surge de novo e aparenemente como solução, é arrancar cabelo no puxão, tacar estrato de bexiga de porco nele, e enfiar na parte careca da cabeça.

:lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol:

Parece uma receita da vovozinha...

Dudu228 escreveu:sem querer arranquei um fio e ele saiu com aquele bulbo, será que já começo a guardar? =P

Jimmy Stewart escreveu:Acho irônico...

Várias empresas tentando criar folículos a partir de técnicas elaboradas, proteínas embrionárias formada em baixa gravidade, cultivo de queratinócitos, cultivo de fibroblastos, tudo que requer avançadas técnicas e método, para saber que mensageiros químicos estimulam isso e aquilo, formas de extrair amostra celulares do folículo para esses cultivos. Milhões de dólares gastos e nenhum grande sucesso, a não ser novos fiapos esparsos aqui em alí...

Mas o que surge de novo e aparenemente como solução, é arrancar cabelo no puxão, tacar estrato de bexiga de porco nele, e enfiar na parte careca da cabeça.

:lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol:

Parece uma receita da vovozinha...

Dudu228 escreveu:sem querer arranquei um fio e ele saiu com aquele bulbo, será que já começo a guardar? =P

tomara que saia algo bom disso ai,se sair a cura,o churrasco e a cervejada é por minha conta.
:mrgreen:

cara isso me desanima... só tem foto das pesquisas multi milionaria das empresas e uns resultados fracos e me deparo com essas fotos:
o Milagre??
Ketoconazole (KCZ), an imidazole anti-fungal agent, is known to be effective for the treatment of seborrheic dermatitis and dandruff. In addition, 2% KCZ shampoo was found to improve hair density and the size and proportion of anagen follicles in androgenetic alopecia (AGA) [1] and, in combination with finasteride, to have an additive effect for AGA [2]. Recently, it has been reported that topical application of KCZ stimulates hair growth in C3H/HeN mice [3]. However, whether topical KCZ is effective enough to improve the clinical appearance of AGA is not yet clear. We therefore carried out an open trial of topical 2% KCZ lotion (Nizoral®) in combination with shampoos. Furthermore, to identify the mechanism, which can explain the clinical effect of KCZ on AGA, we performed transient transfection assays using CV-1 cells transfected with androgen receptors (AR).

The six Japanese males from 23 to 51 years old were enrolled in this study with their written informed consent. They presented with grade II vertex to IVa AGA according to the Hamilton–Norwood classification [4]. The subjects applied topical 2% KCZ lotion (Nizoral®) almost every day during or immediately after hair washing with their own unmedicated shampoos. When they revisited our clinic every several months, clinical pictures were obtained to determine the efficacy of the treatment. Two of the men, one 23 years old with grade II vertex and the other 25 years old with Va AGA, showed remarkable hair regrowth after 6 and 10 months, respectively (Fig. 1). The 23-year-old male stopped using KCZ and 3 months later hair loss recurrence on the vertex was noted (Fig. 1c). When he started using KCZ again during shampooing, hairs on the vertex grew again after 3 months (Fig. 1d). These findings constitute evidence of the clinical efficacy of KCZ for AGA. A 41-year-old male showed a slight increase in vertex hair growth after 1 year. Other three of the men, 31, 38 and 51 years old did not show significant improvement. These findings suggest that topical KCZ with shampoo can be effective for some males with AGA.

Fig. 1. A 23-year-old Japanese man who used 2% ketoconazole (KCZ) lotion during shampooing everyday. Six months later, hair regrowth was attained (b) in comparison with the pre-treatment condition (a). Suspension of use for 3 months, however, caused recurrent hair loss (c). Renewed use of KCZ induced renewed growth of vertex hair (d). A 25-year-old Japanese man with AGA (e) applied 2% KCZ lotion immediately after shampooing everyday. Ten months later, hair regrowth was apparent (f).

To identify the mechanism, which can explain the effect of KCZ on AGA, we performed transient transfection assays using an androgen-responsive synthetic promoter for CV-1 cells transfected with AR. At 50–70% confluency in a 24-well plate, the CV-1 cells, maintained in Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% fetal bovine serum, were transfected with the transfection reagent Fugene-6 (Roche Diagnostics Corp., Indianapolis, IN, USA) according to the manufacturer's instructions. For luciferase assays, we transfected 0.1&#956;g of the reporter plasmid, pGL2-GRE3-bG-luc [5], 12.5ng of pCI-neo-BamX-AR(Gly23) [5] and 0.2&#956;g of the pRL-CMV vector, the Renilla luciferase control reporter vector driven by the CMV immediate-early enhancer/promoter, as the internal controls. At 24h after transfection, we added fresh DMEM supplemented with 10% charcoal-treated fetal bovine serum with methyltrienolone (R1881, a stable synthetic androgen) or ethanol as a mock vehicle. The cells were also treated with KCZ (Janssen, L.P., Titusville, NJ) or ethanol as a mock vehicle. At 48h after transfection, the cells were harvested for luciferase assays. Luciferase activities were measured with a luminometer using the Dual-Luciferase™ reporter assay system (Promega, Madison, WI). The results were summarized from three independent sets of transfections and presented as mean±S.D.; statistical significance was tested with Student's t-test. The results demonstrated that 10 or 20&#956;g/ml KCZ reduced luciferase activity to 67.5% (p<0.01) or 49.9% (p<0.03), respectively, reflecting its suppressive action on AR (Fig. 2). This finding suggests that KCZ improves AGA through the suppression of AR activity.



Fig. 2. KCZ effect on R1881-induced AR transcactivity in CV-1 cells transfected with AR. We used the transfection reagent Fugene-6 (Roche Diagnostics Corp., Indianapolis, IN, USA) to transfect 0.1&#956;g of the reporter plasmid, pGL2-GRE3-bG-luc, 12.5ng of pCI-neo-BamX-AR(Gly23) and 0.2&#956;g of pRL-CMV vector (lanes 1–6) into CV-1 cells cultured at 50–70% confluency in a 24-well plate. The infected cells were treated with 10&#8722;9M R1881 (lanes 2–6) or ethanol as a mock vehicle (lane 1). After overnight incubation, KCZ at the indicated concentration was added to the cultures. The activities of the various reporter genes were compared with the luciferase activity in the presence of R1881 and the absence of KCZ (lane 2).

Dermal papilla cells are the main targets for androgen in hair follicles, as evidenced by immunohistochemistry [6] and reporter assays [7] for the detection of AR. Deep penetration of KCZ into dermal papilla is therefore necessary to realize the suppressive action on androgen in vivo. The use of KCZ in combination with detergent containing shampoos in this study may enhance KCZ penetration. On the other hand, a recent study demonstrated that KCZ stimulates hair growth in mice [3], suggesting that its effect on hair is androgen independent. To summarize, KCZ may exert its effect on AGA in both an androgen-dependent and -independent manner.




References
return to Article Outline

[1]. [1]Pierard-Franchimont C, De Doncker P, Cauwenbergh G, Pierard GE. Ketoconazole shampoo: effect of long-term use in androgenic alopecia. Dermatology. 1998;196:474–477. MEDLINE | CrossRef

[2]. [2]Khandpur S, Suman M, Reddy BS. Comparative efficacy of various treatment regimens for androgenetic alopecia in men. J Dermatol. 2002;29:489–498. MEDLINE

[3]. [3]Jiang J, Tsuboi R, Kojima Y, Ogawa H. Topical application of ketoconazole stimulates hair growth in C3H/HeN mice. J Dermatol. 2005;32:243–247. MEDLINE

[4]. [4]Norwood OT. Male pattern baldness: classification and incidence. South Med J. 1975;68:1359–1365. MEDLINE

[5]. [5]Inui S, Nakao T, Itami S. Modulation of androgen receptor transcriptional activity by anti-acne reagents. J Dermatol Sci. 2004;36:97–101. Abstract | Full Text | Full-Text PDF (135 KB) | MEDLINE | CrossRef

[6]. [6]Itami S, Kurata S, Sonoda T, Takayasu S. Interaction between dermal papilla cells and follicular epithelial cells in vitro: effect of androgen. Br J Dermatol. 1995;132:527–532. MEDLINE

[7]. [7]Inui S, Itami S, Pan HJ, Chang C. Lack of androgen transcriptional activity in human keratinocytes. J Dermatol Sci. 2000;23:87–92. Abstract | Full Text | Full-Text PDF (106 KB) | MEDLINE | CrossRef


http://www.hairsite.com/hair-loss/board ... -DESC.html

Sei não... O Hellboy invadiria seu churrasco, pois viria vestido como travestí e diria que é a Sandrinha bombom.

careca de franja escreveu:tomara que saia algo bom disso ai,se sair a cura,o churrasco e a cervejada é por minha conta.
:mrgreen:

Jimmy Stewart escreveu:Sei não... O Hellboy invadiria seu churrasco, pois viria vestido como travestí e diria que é a Sandrinha bombom.

careca de franja escreveu:tomara que saia algo bom disso ai,se sair a cura,o churrasco e a cervejada é por minha conta.
:mrgreen:

não duvido nada.
:lol: :lol: :lol: :lol: :lol:

acabou de ter uma entrevista de uma hora com o Dr cooley!

ele tentou apaziguar o maximo! mas pelo que entendi nao pode ser conciderado uma cura, pq nunca vai ser igual e com mesma densidade da cabeleiraanterior,
mas desde o finasterida foi sem duvida a coisa mais promissora na area! nao da pra explicar td aqui mas o site vai postar alguns segmentos no site dele das melhores partes da entrevista.
so sei que vou dormir feliz hj.

zooi escreveu:acabou de ter uma entrevista de uma hora com o Dr cooley!

ele tentou apaziguar o maximo! mas pelo que entendi nao pode ser conciderado uma cura, pq nunca vai ser igual e com mesma densidade da cabeleiraanterior,
mas desde o finasterida foi sem duvida a coisa mais promissora na area! nao da pra explicar td aqui mas o site vai postar alguns segmentos no site dele das melhores partes da entrevista.
so sei que vou dormir feliz hj.

se for isso mesmo hein.
que alegria que vai ser.
:mrgreen:

Aqui esta a pagina com a entrevista feita a Jerry Cooley: http://www.hairlossexperiences.com/view ... d=2&page=2

È só traduzir,interessante!

http://www.iahrs.org/news/dr-jerry-cool ... sentation/

olha issooo

http://www.iahrs.org/news/dr-jerry-cool ... -part-3-4/


c for td verdade, bora marca um festa da galera do forum
isso ai merece

acell... histogen...

ta chegando papai.. ta chegando...

:lol: